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Original Article
Serogroup and Antimicrobial Resistance of Streptococcus pneumoniae Isolated from Oropharynx in Children Attending Day Care Center
Kyung Hyo Kim, Jong Eun Lee, Il Tae Whang, Kyung Ha Ryu, Young Mi Hong, Gyoung Hee Kim, Keun Lee, Eun-Suk Kang, Ki-Sook Hong
Clin Exp Pediatr. 2002;45(3):346-353.   Published online March 15, 2002
Purpose : Penicillin- and multidrug-resistant S. pneumoniae poses a serious threat to clinicians because the rate of resistance of S. pneumoniae to penicillin in Korea has surged up to the world's highest level. This study was performed to assess the carriage rate, serogroups and antimicrobial susceptibility of S. pneumoniae isolated from oropharynx in children. Methods : From March to July 1998,...
Evaluation of Health Status and Growth and Developmental Outcome of Intrauterine Growth-Retarded Infants
Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
Clin Exp Pediatr. 2001;44(6):635-641.   Published online June 15, 2001
Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants. Methods : Sixty five intrauterine growth retarded...
Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1999;42(7):921-927.   Published online July 15, 1999
Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord...
Effects of Thioredoxin on Apoptosis-Inducing Neuronal Cell Injury
Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee
Clin Exp Pediatr. 1999;42(6):825-832.   Published online June 15, 1999
Purpose : Thioredoxin is an endogenous antioxidant. It regulates the activities of transcriptional factors such as NF-kB(nuclear factor kappa B)and AP-1(activator protein-1) and it increases the synthesis of cytokines, preventing cellular proliferation and apoptosis. The aim of this study was to clarify the role of thioredoxin on apoptosis-inducing neuronal cell injury. We investigated the protective effects of thioredoxin against apoptosis-inducing...
Effects of Thioredoxin on Oxidative Neuronal Cell Injury
Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee
Clin Exp Pediatr. 1999;42(5):686-696.   Published online May 15, 1999
Purpose : Thioredoxin is an endogenous antioxidant which directly scavenges reactive oxygen species(ROS) and regenerates oxidatively damaged protein by reducing potential at the redox active disulfide(-Cys-Gly-Pro-Cys-) site. Under oxidative stress, thiredoxin plays a protective and adaptative role by inducing expressions. The aim of this study was to clarify the role of thioredoxin on oxidative neuronal cell injury. We investigated the...
Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid
Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh,
Clin Exp Pediatr. 1999;42(4):462-471.   Published online April 15, 1999
Purpose : During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies. Methods : HL-60 cells were induced to differentiate by adding 1μM ATRA. On the 4th and 7th day after stimulation as well as before stimulation, the cells were analyzed for phenotypic and...
Functional Differentiation of HL-60 Cells by Dimethylsulfoxide and Phorbol 12-myristate 13-acetate
Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
Clin Exp Pediatr. 1999;42(3):355-363.   Published online March 15, 1999
Purpose : During hematopoietic differentiation of HL-60 cells by DMSO and PMA, we demonstrated functional changes of HL-60 cells-phagocytic activity, respiratory burst, antibody-dependent cell-mediated cytotoxicity(ADCC) and opsonophagocytic activity. Methods : HL-60 cells(ATCC CCL-240), cultured in RPMI 1640 and supplemented with 10% FBS, were induced to differentiate by adding 1.0% DMSO or 16nM PMA. On the 4th and 7th day after...
Effects of Two Different Surfactants on RBC Membrane and Type Ⅱ Alveolar Epithelial Cell in Vitro
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1999;42(1):32-39.   Published online January 15, 1999
Purpose : Respiratory distress syndrome(RDS) is a major cause of death in premature babies. For the treatment of RDS, various artificial pulmonary surfactants have been used. The incidence of pulmonary hemorrhage is increased in association with surfactant therapy in extremely low birth weight infants. But the pathogenesis of this increased incidence is not clear. So we conducted this study...
Inhibitory Effects of Actinomycin-D and Pentoxifylline on the Production of IL-1α and TNF-α by Human Cord and Adult Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(12):1700-1708.   Published online December 15, 1998
Purpose : An area of intense intrest is assessment of new therapeutic modalities that regulate the inflammatory response in acute bacterial infection is proving to be an area of interest these days. So we conducted this study to compare the inhibitory effects of actinomycin-D and pentoxifylline on the production of IL-lα and TNF-α from cord blood mononuclear cells(MC) to those...
Diagnostic Sensitivity in Predicting Hyperlipidemia by Bioelectrical Impedance Analysis in Obese Children
Ji Ah Jung, Hyun Mi Kim,, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(11):1583-1589.   Published online November 15, 1998
Purpose : Childhood obesity is currently on the rise. The complications of childhood obesity are depression, adult obesity, hypertension, diabetes, hyperlipidemia, coronary artery disease and fatty liver. Therefore, accurate diagnosis of obesity is important. The purpose of this study was to assess diagnostic sensitivity to predict hypelipidemia by bioelectrical impedance analysis(BI) in obese children. Methods : One hundred fifteen healthy...
Immunologic Changes of HL-60 Cells by Differentiation Inducing Agents I : Phenotypic Differentiation of FcγR and Mac-1
Hye Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
Clin Exp Pediatr. 1998;41(10):1342-1350.   Published online October 15, 1998
Purpose : Fc receptors and Mac-1 play an important role in the protective response of granulocytes and monocytes against microbial infection. FcγRⅠ, FcγRⅡ, FcγRⅢ as well as CD11b/ CD18 have never been measured in a quantitative way during hemopoiesis. Thus we quantified the expression of FcγRⅠ, FcγRⅡ, FcγRⅢ, and CD11b/CD18 during hematopoietic differentiation using HL-60 cells, which was induced to...
Study of Seroprevalence of Antimycoplasma Antibody in Healthy Children and its Diagnostic Value
Soo Kyung Choi, Ji Ah Jung, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(4):489-497.   Published online April 15, 1998
Purpose : To evaluate the diagnostic reliability of the single serum titers of the specific serum antibody determiantion method, we compared antimycoplasma antibody titers of 177 healthy children with 353 children who had respiratory symptoms indicative of Mycoplasma pneumoniae infection. Methods : We used Serodia-Myco II particle agglutination test and the titers of ≥1:40 were regarded as positive. Results : Age distribution of 177 healthy...
Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(3):338-345.   Published online March 15, 1998
Purpose : We performed a pulmonary function test with simple, computerized spirometry composed of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes in healthy Korean children. We calculated each of the simple and complex linear and logarithmic regression equations setting the predicted values. Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to August, 1995....
The Espression of Fcγ Receptors and Mac-1 in Cord and Adult Blood Monocytes and Lymphocytes and Production of Interleukin-8 by Cord and Adult Blood Mononeuclear Cells Stimulated by Lipopolysacchride
Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(12):1660-1669.   Published online December 15, 1997
Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fcmoiety of IgG(FcγR) are important in antibodymediated clearance of microbes by monocytes/macrophages and immune regulation in lymphocytes. As an approach to understanding their role in neonatal life, we have compared the constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)-by neonatal and adult blood monocytes...
Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(7):981-990.   Published online July 15, 1997
Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract infection are analyzed in children with acute urinary tract infection. Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method. Results...
A Clinical Study for the Time of Development and Risk Factors of Retinopathy of Prematurity
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(7):945-954.   Published online July 15, 1997
The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes
Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh, Hae-Kyung Park
Clin Exp Pediatr. 1997;40(6):794-800.   Published online June 15, 1997
Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult...
Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(5):690-700.   Published online May 15, 1997
Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited...
Plasma Fibronectin Concentration in the Premature,Fullterm Neonates and Infants
Hyun Joo Lee, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(4):473-479.   Published online April 15, 1997
Purpose : Plasma fibronectin has important role in the inflammatory response as non-specific opsonin and host defense. Plasma fibronectin concentration is different according to age and presence of infection. We performed this study to evalulate plasma fibronectin concentration in the healthy preterm, term neonates and infants and how that correlate with gestational age and birth weight and increased CRP concentration....
The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
Hyunmi Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(6):829-838.   Published online June 15, 1996
Purpose : Neonatal seizure is usually the presentation of underlying neurologic dysfunction rather than a disease and have high mortality and morbidity as sequalae. Therefore, the parameter predicting the neurologic prognosis is necessary. This study was performed to identify the usefulness of clinical scoring as predictor in neonatal seizure by analyzing outcomes. Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive...
Serum Secretory CD4 and CD8 Levelsin Kawasaki Disease
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(4):543-551.   Published online April 15, 1996
Purpose : Kawasaki disease (KD) is an acute febrile illness of infancy and early childhood characterized by diffuse vasculitis. Although the disease is generally self-limited, up to 25% of untreated patients with KD may develop coronary artery abnormalities. The acute phase of KD is characterized by marked activation of the immune system leading to increased cytokine production by immune effector...
Evaluation of Pulmonary Function Test by Pneumotachography and Passive Expiratory Flow-volume Technique in Newborns with Respiratory Diseases with Respiratory Diseases
Hye Jin Lee, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(4):482-490.   Published online April 15, 1996
Purpose : Pulmonary function test is an important diagnostic tool in neonatal intensive care. These tests provide a detailed assessment an infant's pulmonary status that can be used in several ways: to monitor the progression of lung disease, to streamline ventilator management, and to assess the infant's response to new treatments, such as surfactant replacement therapy or bronchodilator. The purpose...
Pulmonary Function Test in Korean Neonates by Expiratory Flow-Volume Curve
So Young Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(1):53-62.   Published online January 15, 1996
Purpose : Neonatal pulmonary function test(PFT) adds a new dimension to the understanding and care of the infant at risk for lung dysfunction. PFT can be identified the risk for pulmonary problems and safely and effectively diagnosed, quantified, and qualified the dysfunction. So it is possible to early institution of prophylatic respiratory therapy in such neonates and it can improved...
Case Report
A Case of Meckel-Gruber Syndrome
Hye Jin Lee, Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1299-1303.   Published online September 15, 1995
We report a case of male neonate that showed multiple congenital anomalies that could be designated as Meckel-Gruber syndrome. The principle signs of Meckel-Gruber syndrome are encephaolcelem, polydactly, and polycystic kidneys with normal karyotype. Due to rarity of the Meckel-Gruber syndrome, the cause was still unknown. At present, autosomal recessive is thought to be as one of the causes. This malformation...
Original Article
Natural Anti-PRP Antibody Levels to Haemophilus Influenzae Type b(Hib) and Changes of Antibody Levels after Three Doses of Vacination
Eun Sun Yoo, Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1201-1209.   Published online September 15, 1995
Purpose : The Haemophilus influenzae type b(Hib) was the most common cause of meningitis and invasive bacterial disease mainly in children 2 months to 5 years old in the United States. The conjugated Hib vaccines have recently been licensed by the US Food and Drug Administration for routine use in infants beginning at 2 months of age, and the Infectious...
Riboflavin Status of Normal Newborn Infants and the Changes of Riboflavin During Phototherapy in Hyperbilirubinemic Newborn Newborn Infants
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1185-1192.   Published online September 15, 1995
Purpose : Riboflavin is the most important water soluble vitamin in infant nutrition. Riboflavin is converts to flavin mononucleotide (FMN), Flavin adenine dinucleotide(FAD) and then, participiates in the metabolism of energy, protein cellular oxidation-reduction reactions as a cofactor of reactions. Also riboflavin, a light sensitive vitamin, has a maximum absorption spectrum at a wave length similar to that at which...
Case Report
Laryngotracheoesophageal Cleft Type III A Report of 1 Case
Myung Su Lee, Young Eun Lee, Eun Ae Park, Gyoung Hee Kim, Eun Chul Chung, Hac Soo Gyu
Clin Exp Pediatr. 1995;38(5):719-724.   Published online May 15, 1995
Laryngotracheoesophageal cleft is rare congenital anomaly due to failure of fusion of the e sophagus and the larynx. We experienced 1 case of larygotracheoesophageal cleft type III in neonate which was confirmed by autopsy. One day of age male newborn infant with grunting, retraction, and copious secretion canofirm diagnosis as laryngotracheoesophageal cleft type Ill by several radiographic studies and sutopsy. Brief review and...
Original Article
Comparative Study on the Allergy Skin Test and RAST in Allergic Patients
Il Tae Whang, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1994;37(12):1693-1700.   Published online December 15, 1994
The allegic skin test and RAST are used commonly to demonstrate the presence of skin sensitizing IgE antibody in the diagnosis of allergic disease. To evaluate the agreement rate and correlation between results of skin test and RAST (radioallergosorbent test) in allergic subject, 83 allergic childgood with positive skin test (bronchial asthma: 26, allergic rhinitis: 27, atopic dermatitis and urticaria: 6...
Evaluation of Pulmonary Venous, Mitral and Aortic Flow Pattern by Doppler Echocardiography in Neonates
Hye Soon Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1994;37(5):596-605.   Published online May 15, 1994
Pulmonary vein velocities have recently been estimated in conjunction with mitral flow velocities to increase our understanding of ventricular filling. The advent of transesophageal echocardiography with pulsed doppler imaging capability has provided a method by which both the mitral valve and pulmonary vein velocities can be easily recorded because of the posterior approach providing unimpeded interrogation of cardiac structures. The purpose...
Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children
Young Mi Hong, Kyung Hyo Kim, Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1993;36(10):1651-1358.   Published online October 15, 1993
For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with...
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